Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

In the cell, the proteasome and lysosomes represent the most important proteolytic
machineries, responsible for the protein degradation in the ubiquitin–proteasome system …

Cypermethrin (CMN) is a man-made insecticide, and its abuse has led to potential adverse
effects, particularly in sensitive populations such as aquatic organisms. The present study …

Aims We have shown previously that non-toxic inhibition of the ubiquitin–proteasome
system upregulates antioxidative defence mechanisms and protects endothelial cells from …

Proper protein turnover is required for cardiac homeostasis and, accordingly, impaired
proteasomal function appears to contribute to heart disease. Specific proteasomal …

Rationale: Mutations in the MYBPC3 gene encoding cardiac myosin-binding protein
(cMyBP)-C are frequent causes of hypertrophic cardiomyopathy, but the mechanisms …

Pathologic heart conditions, particularly heart failure (HF) and ischemia-reperfusion (I/R)
injury, are characterized by sustained elevation of plasma and interstitial catecholamine …

Protein quality control (PQC) depends on elegant collaboration between molecular
chaperones and targeted proteolysis in the cell. The latter is primarily carried out by the …

It is believed that cardiac remodeling due to geometric and structural changes is a major
mechanism for the progression of heart failure in different pathologies including …

Background—Cardiac overload, a major cause of heart failure, induces the expression of
the heat shock protein H11 kinase/Hsp22 (Hsp22). Methods and Results—To determine the …