Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Exploiting the mechanical effects of ultrasound for noninvasive therapy
MA O'Reilly - Science, 2024 - science.org
Focused ultrasound is a platform technology capable of eliciting a wide range of biological
responses with high spatial precision deep within the body. Although focused ultrasound is …
responses with high spatial precision deep within the body. Although focused ultrasound is …
A tool for monitoring cell type–specific focused ultrasound neuromodulation and control of chronic epilepsy
Focused ultrasound (FUS) is a powerful tool for noninvasive modulation of deep brain
activity with promising therapeutic potential for refractory epilepsy; however, tools for …
activity with promising therapeutic potential for refractory epilepsy; however, tools for …
Intrathecal delivery of Macromolecules: Clinical status and emerging technologies
The proximity and association of cerebrospinal fluid (CSF) and the intrathecal (IT) space with
deep targets in the central nervous system (CNS) parenchyma makes IT injection an …
deep targets in the central nervous system (CNS) parenchyma makes IT injection an …
Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound
Transport of interstitial fluid and solutes plays a critical role in clearing metabolic waste from
the brain. Transcranial application of focused ultrasound (FUS) has been shown to promote …
the brain. Transcranial application of focused ultrasound (FUS) has been shown to promote …
[HTML][HTML] Multivariable-incorporating super-resolution residual network for transcranial focused ultrasound simulation
Background and objective: Transcranial focused ultrasound (tFUS) has emerged as a new
non-invasive brain stimulation (NIBS) modality, with its exquisite ability to reach deep brain …
non-invasive brain stimulation (NIBS) modality, with its exquisite ability to reach deep brain …
tFUSFormer: Physics-guided super-resolution Transformer for simulation of transcranial focused ultrasound propagation in brain stimulation
Transcranial focused ultrasound (tFUS) has emerged as a new mode of non-invasive brain
stimulation (NIBS), with its exquisite spatial precision and capacity to reach the deep regions …
stimulation (NIBS), with its exquisite spatial precision and capacity to reach the deep regions …
Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents
Cerebrospinal fluid (CSF) is crucial for maintaining neuronal homeostasis, providing
nutrition, and removing metabolic waste from the brain. However, the relationship between …
nutrition, and removing metabolic waste from the brain. However, the relationship between …
High incidence of intracerebral hemorrhaging associated with the application of low-intensity focused ultrasound following acute cerebrovascular injury by intracortical …
Low-intensity transcranial focused ultrasound (FUS) has gained momentum as a non-
/minimally-invasive modality that facilitates the delivery of various pharmaceutical agents to …
/minimally-invasive modality that facilitates the delivery of various pharmaceutical agents to …
[HTML][HTML] Transcranial focused ultrasound stimulation enhances cerebrospinal fluid movement: Real-time in vivo two-photon and widefield imaging evidence
Background Cerebrospinal fluid (CSF) flow is crucial for brain homeostasis and its
dysfunction is highly associated with neurodegenerative diseases. Restoring CSF …
dysfunction is highly associated with neurodegenerative diseases. Restoring CSF …