[HTML][HTML] Context-dependent, fuzzy protein interactions: Towards sequence-based insights
M Fuxreiter - Current Opinion in Structural Biology, 2024 - Elsevier
Predicting protein interactions in the cellular environment still remains a challenge in the
AlphaFold era. Protein interactions, similarly to their structures, sample a continuum from …
AlphaFold era. Protein interactions, similarly to their structures, sample a continuum from …
Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring
TAF Gadeberg, MH Jørgensen, HG Olesen… - Nature Structural & …, 2025 - nature.com
The C3 protein is the central molecule within the complement system and undergoes
proteolytic activation to C3b in the presence of pathogens. Pattern-independent activation of …
proteolytic activation to C3b in the presence of pathogens. Pattern-independent activation of …
Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein
SL Harwood, GR Andersen… - Proceedings of the …, 2022 - National Acad Sciences
Luque et al. have described multiple structures of human alpha-2-macroglobulin (A2M)
determined from samples purified from frozen human plasma (1). The authors interpreted …
determined from samples purified from frozen human plasma (1). The authors interpreted …
Proteolytic cleavage of the TGF β co‐receptor CD 109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the …
KT Jensen, NS Nielsen, A Viana Almeida… - The FEBS …, 2024 - Wiley Online Library
The glycosylphosphatidylinositol (GPI)‐anchored protein cluster of differentiation 109
(CD109) is expressed on many human cell types and modulates the transforming growth …
(CD109) is expressed on many human cell types and modulates the transforming growth …
The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel
SL Harwood, K Diep, NS Nielsen, KT Jensen… - Journal of Biological …, 2022 - ASBMB
The protease inhibitor α 2-macroglobulin (A2M) is a member of the ancient α 2-
macroglobulin superfamily (A2MF), which also includes structurally related proteins, such as …
macroglobulin superfamily (A2MF), which also includes structurally related proteins, such as …
Engineering New Protease Inhibitors Using α2-Macroglobulin
SL Harwood, JJ Enghild - Proteases and Cancer: Methods and Protocols, 2023 - Springer
Protease inhibitors of the alpha-macroglobulin family (αM) have a unique mechanism that
allows them to trap proteases that is dependent not on the protease's class, but rather on its …
allows them to trap proteases that is dependent not on the protease's class, but rather on its …
Audiologic Measures in an Indigenous Community with A2ML1- and FUT2-Related Otitis Media
RLP Santos-Cortez, KMC Ong… - Genetic Testing and …, 2023 - liebertpub.com
Background: Many indigenous peoples are at elevated risk for otitis media, however there is
limited information on hearing loss due to OM in these communities. An Indigenous Filipino …
limited information on hearing loss due to OM in these communities. An Indigenous Filipino …