Toxicity of Doxorubicin (Dox) to different experimental organ systems
A Pugazhendhi, TNJI Edison, BK Velmurugan… - Life sciences, 2018 - Elsevier
Doxorubicin (Dox) is a valuable anticancer drug for hematologic and solid tumors. Yet, it can
cause multi-organ toxicities in various patients. Since toxicity evaluation is a major criterion …
cause multi-organ toxicities in various patients. Since toxicity evaluation is a major criterion …
Toxic effects and molecular mechanism of doxorubicin on different organs–an update
K Renu, LP Pureti, B Vellingiri… - Toxin …, 2022 - Taylor & Francis
Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …
Colchicine ameliorates dilated cardiomyopathy via SIRT2‐mediated suppression of NLRP3 Inflammasome activation
X Sun, J Duan, C Gong, Y Feng, J Hu… - Journal of the American …, 2022 - Am Heart Assoc
Background Dilated cardiomyopathy remains a leading cause of heart failure worldwide.
Immune inflammation response is recognized as a significant player in the progression of …
Immune inflammation response is recognized as a significant player in the progression of …
[HTML][HTML] Protective effect of diosmin against doxorubicin-induced nephrotoxicity
Doxorubicin (Dox) is an anthracycline antibiotic that is primarily used for treating various
solid tumors including that of pulmonary, ovary, breast, uterine, cervix, and several blood …
solid tumors including that of pulmonary, ovary, breast, uterine, cervix, and several blood …
[HTML][HTML] N-Acetylcysteine may exert hepatoprotective effect by regulating Meteorin-Like levels in Adriamycin-induced liver injury
Adriamycin (ADR) is an important chemotherapeutic drug, but it has serious side effects
such as hepatotoxicity. This study aimed to evaluate whether N-acetylcysteine (NAC) has …
such as hepatotoxicity. This study aimed to evaluate whether N-acetylcysteine (NAC) has …
Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis
Background: Doxorubicin (DOX) is used for treatment of many cancer types. Thymoquinone
(THQ) is a powerful antioxidant agent used for reducing side effects of several drugs. The …
(THQ) is a powerful antioxidant agent used for reducing side effects of several drugs. The …
Role of flavonoids against adriamycin toxicity
MD Navarro-Hortal, A Varela-López… - Food and Chemical …, 2020 - Elsevier
Abstract Doxorubicin (DOX), or adriamycin, is an anthracycline antineoplastic drug widely
used in the chemotherapy of a large variety of cancers due to its potency and action …
used in the chemotherapy of a large variety of cancers due to its potency and action …
Therapeutic effects of thymoquinone in doxorubicin‐induced hepatotoxicity via oxidative stress, inflammation and apoptosis
Cancer is a lethal disease that is characterized by uncontrolled cell division and
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …
proliferation, and it results in death in many organisms. Doxorubicin (DOX) is a therapeutic …
Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in …
Despite the effectiveness of doxorubicin (DOX) in the management of a wide range of
cancers, a major challenge is its cardio-toxic effect. Oxidative stress, inflammation, and …
cancers, a major challenge is its cardio-toxic effect. Oxidative stress, inflammation, and …
Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress
The aim of the present study was to investigate the therapeutic and protective effects of
linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were …
linalool against doxorubicin (DOX)-induced kidney injury. Forty-eight Wistar rats were …