Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Centrioles are microtubule-based core components of centrosomes and cilia. They are
duplicated exactly once during S-phase progression. Central to formation of each new …

Inhibitors of mitotic protein kinases are currently being developed as non-neurotoxic
alternatives of microtubule-targeting agents (taxanes, vinca alkaloids) which provide a …

Centrosomes and primary cilia are usually considered as distinct organelles, although both
are assembled with the same evolutionary conserved, microtubule-based templates, the …

Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This
family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator …

Tight control of centriole duplication is critical for normal chromosome segregation and the
maintenance of genomic stability. Polo-like kinase 4 (Plk4) is a key regulator of centriole …

The centriole is a multifunctional structure that organizes centrosomes and cilia and is
important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole …

Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating
the formation of primary cilia. Centriole duplication occurs once per cell cycle and is …