Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …

An important mechanism of posttranscriptional gene regulation in mammalian cells is the
rapid degradation of messenger RNAs (mRNAs) signaled by AU-rich elements (AREs) in …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

An important paradigm for post‐transcriptional regulation is the control of cytoplasmic mRNA
stability mediated by AU‐rich elements (AREs) in the 3′ untranslated region of transcripts …

HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal
posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under …

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor whose expression is
dramatically induced by hypoxia due in large part to an increase in the stability of its mRNA …

Colorectal carcinoma RKO cells expressing reduced levels of the RNA‐binding protein HuR
(ASHuR) displayed markedly reduced growth. In synchronous RKO populations, HuR was …

Genomic array technologies provide a means for profiling global changes in gene
expression under a variety of conditions. However, it has been difficult to assess whether …

Spinal muscular atrophy (SMA) results from reduced levels of the survival of motor neuron
(SMN) protein, which has a well characterized function in spliceosomal small nuclear …

AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene,
cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously …