Applications of Nanopore sequencing in precision cancer medicine
SA Dyshlovoy, S Paigin, AK Afflerbach… - … Journal of Cancer, 2024 - Wiley Online Library
Abstract Oxford Nanopore Technologies sequencing, also referred to as Nanopore
sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential …
sequencing, stands at the forefront of a revolution in clinical genetics, offering the potential …
[HTML][HTML] Cytogenetics in the management of hematological malignancies: an overview of alternative technologies for cytogenetic characterization
V Lestringant, H Guermouche-Flament… - Current Research in …, 2024 - Elsevier
Genomic characterization is an essential part of the clinical management of hematological
malignancies for diagnostic, prognostic and therapeutic purposes. Although CBA and FISH …
malignancies for diagnostic, prognostic and therapeutic purposes. Although CBA and FISH …
Silencing of the DNA damage repair regulator PPP1R15A sensitizes acute myeloid leukemia cells to chemotherapy
A Bouchla, CD Sotiropoulou, C Esteb, T Loupis… - Annals of …, 2024 - Springer
Abstract Acute Myeloid Leukemia (AML) is a life-threatening disease whose induction
treatment consists of combination chemotherapy with Idarubicin and Cytarabine for fit …
treatment consists of combination chemotherapy with Idarubicin and Cytarabine for fit …
Chromothripsis in myeloid malignancies
CY Chen - Annals of Hematology, 2024 - Springer
Chromothripsis refers to massive genomic rearrangements developed during a catastrophic
event. In total acute myeloid leukemia (AML), the incidence of chromothripsis ranges from 0 …
event. In total acute myeloid leukemia (AML), the incidence of chromothripsis ranges from 0 …
Successful classification of clinical pediatric leukemia genetic subtypes via structural variant detection using HiFi long-read sequencing
LA Lansdon, B Yoo, A Keskus, I Pushel, C Bi, T Ahmad… - medRxiv, 2024 - medrxiv.org
Gene fusions are common primary drivers of pediatric leukemias and are the result of
underlying structural variant (SVs). Current clinical workflows to detect such alterations rely …
underlying structural variant (SVs). Current clinical workflows to detect such alterations rely …
The prognostic impact of C‐reactive protein and albumin in patients diagnosed with acute myeloid leukaemia
ET Skar, Ø Wendelbo, H Reikvam - eJHaem, 2024 - Wiley Online Library
Background Acute myeloid leukaemia (AML) is an aggressive and heterogeneous
malignant disease. Patient age, comorbidities and disease‐specific genetic abnormalities …
malignant disease. Patient age, comorbidities and disease‐specific genetic abnormalities …
[HTML][HTML] Chromothripsis in hematological malignancies
FA Lagunas-Rangel - Experimental Hematology, 2024 - Elsevier
Chromotrypsis, a phenomenon resulting from catastrophic mitotic errors and genomic
instability, is defined by the occurrence of multiple DNA double-strand breaks in one or more …
instability, is defined by the occurrence of multiple DNA double-strand breaks in one or more …