Dynamic stem cell states: naive to primed pluripotency in rodents and humans
L Weinberger, M Ayyash, N Novershtern… - … reviews Molecular cell …, 2016 - nature.com
The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network
Embryonic stem cells (ESCs) can be maintained in culture indefinitely while retaining the
capacity to generate any type of cell in the body, and therefore not only hold great promise …
capacity to generate any type of cell in the body, and therefore not only hold great promise …
Derivation of novel human ground state naive pluripotent stem cells
O Gafni, L Weinberger, AAF Mansour, YS Manor… - Nature, 2013 - nature.com
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …
Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure
Y Yang, K Adachi, MA Sheridan… - Proceedings of the …, 2015 - National Acad Sciences
Human pluripotent stem cells (PSCs) show epiblast-type pluripotency that is maintained with
ACTIVIN/FGF2 signaling. Here, we report the acquisition of a unique stem cell phenotype by …
ACTIVIN/FGF2 signaling. Here, we report the acquisition of a unique stem cell phenotype by …
From engineering to editing the rat genome
S Meek, T Mashimo, T Burdon - Mammalian Genome, 2017 - Springer
Since its domestication over 100 years ago, the laboratory rat has been the preferred
experimental animal in many areas of biomedical research (Lindsey and Baker The …
experimental animal in many areas of biomedical research (Lindsey and Baker The …
Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C
Background Changes in metabolic pathway preferences are key events in the
reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs). The …
reprogramming process of somatic cells to induced pluripotent stem cells (iPSCs). The …
The attenuation of epithelial to mesenchymal transition and induction of anoikis by gigantol in human lung cancer H460 cells
T Unahabhokha, P Chanvorachote… - Tumor Biology, 2016 - Springer
Lung cancer has been the major cause of death within patients due to the high metastatic
rate. One of the most essential processes of metastasis is the ability of cancer cells to resist …
rate. One of the most essential processes of metastasis is the ability of cancer cells to resist …
Characterization of a Distinct State in the Continuum of Pluripotency Facilitated by Inhibition of PKCζ in Mouse Embryonic Stem Cells
I Baral, MB Shirude, DL Jothi, A Mukherjee… - Stem Cell Reviews and …, 2023 - Springer
Inhibition of PKC (PKCi) signaling maintains pluripotency of embryonic stem cells (ESCs)
across different mammalian species. However, the position of PKCi maintained ESCs in the …
across different mammalian species. However, the position of PKCi maintained ESCs in the …
Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism
PP Phiboonchaiyanan, C Kiratipaiboon… - Chemico-biological …, 2016 - Elsevier
Cancer stem cells (CSCs), a subpopulation of cancer cells with high aggressive behaviors,
have been identified in many types of cancer including lung cancer as one of the key …
have been identified in many types of cancer including lung cancer as one of the key …