Mitochondria are primarily involved in energy production through the process of oxidative
phosphorylation (OXPHOS). Increasing evidence has shown that mitochondrial function …

Oxidative stress (OS) arises when the body is subjected to harmful endogenous or
exogenous factors that overwhelm the antioxidant system. There is increasing evidence that …

Aging is characterized by functional decline in homeostatic regulation and vital cellular
events. This process can be linked with the development of cardiovascular diseases (CVDs) …

Androgen deprivation therapy (ADT) is successfully used in patients with advanced prostatic
cancer, but there are many concerns about its systemic side effects, especially due to …

Aging causes degenerative changes such as epigenetic changes and mitochondrial
dysfunction in skeletal muscle. Exercise can upregulate muscle mitochondrial homeostasis …

Epigenetic modifications influence gene expression programs ultimately dictating
physiological outcomes. In the past decades, an increasing body of work has demonstrated …

Advancements in understanding skin aging mechanisms, which encompass both external
and internal aging processes, have spurred the development of innovative treatments …

Many anticancer therapies (CTx) have cardiotoxic side effects that limit their therapeutic
potential and cause long-term cardiovascular complications in cancer survivors. This has …

Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers,
demonstrating substantial plasticity. Physiological or pathological stimuli can induce …

Mitochondria are critical organelles that provide energy as ATP to the cell. Besides 37 genes
encoded by mitochondrial genome, it has been estimated that over 1500 nuclear genes are …