Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The
effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as …

Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

Activation of the dynorphin/κ-opioid receptor (KOR) system by repeated stress exposure or
agonist treatment produces place aversion, social avoidance, and reinstatement of …

Mood disorders cause much suffering and lost productivity worldwide, compounded by the
fact that many patients are not effectively treated by currently available medications. The …

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal disorder characterized by
periods of activity and remission. IBD includes Crohn's disease (CD) and ulcerative colitis …

Serotonin modulates a variety of processes throughout the brain, but it is perhaps best
known for its involvement in the etiology and treatment of depressive disorders …

Growing evidence supports involvement of low-affinity/high-capacity organic cation
transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in regulating …

Abstract Serotonin‐1B (5‐HT1B) autoreceptors are located in serotonin (5‐HT) terminals,
along with serotonin transporters (SERT), and play a critical role in autoregulation of …

Depression is among the most common psychiatric disorders, and in many patients a
disorder for which available medications provide suboptimal or no symptom relief. The most …

In the conventional model of serotonin neurotransmission, serotonin released by neurons in
the midbrain raphe nuclei exerts its actions on forebrain neurons by interacting with a large …