Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …

The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways
such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling …

Importance Although bevacizumab has been used in the treatment of ovarian cancer, its
optimal use is unknown. Objective To investigate time-dependent changes in the outcomes …

Maintenance of tumor vasculature integrity is indispensable for tumor growth and thus
affects tumor progression. Previous studies have identified platelets as major regulators of …

The potential of altering the tumor ECM to improve drug response remains fairly unexplored.
To identify targets for modification of the ECM aiming to improve drug response and …

A conventional theranostic system usually employs a single fluorescence channel to show
the pharmacokinetic events, which usually fails to quantitatively reveal the true cumulative …

The tumor microenvironment (TME) plays an important role in various stages of tumor
generation, metastasis, and evasion of immune monitoring and treatment. TME targeted …

Bevacizumab, an anti-VEGF antibody, targets mainly tumor blood vessels and exerts a
cytostatic antitumor effect. In primary ovarian cancer, bevacizumab is used for 15 months …

Cancer stem cells are a subset of cells within the tumor that possess the ability to self-renew
as well as differentiate into different cancer cell lineages. The exact mechanisms by which …