The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models
with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia …

An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive
form of adrenal failure, exists in a genetically isolated Irish population. In addition to …

Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia.
Using rapid amplification of 5′ complementary DNA ends in human brain, we identified a …

Adhesive receptors of the integrin family are primarily involved in cell–extracellular matrix
adhesion. Additionally, integrins trigger multiple signaling pathways that are involved in cell …

Human ether-á-go-go–related gene (hERG) potassium channels have voltage-dependent
closing (deactivation) kinetics that are unusually slow. A Per-Arnt-Sim (PAS) domain in the …

Mammalian ether‐à‐go‐go (EAG) channels are voltage‐gated K+ channels. They are
encoded by the KCNH gene family and divided into three subfamilies, eag (Kv10), erg (eag …

The consumption of flavonoid-rich foods, in particular fruits and vegetables, has been
epidemiologically associated with a reduced risk of heart disease, neurodegenerative …

Neurological disorders including depression, anxiety, post-traumatic stress disorder (PTSD),
schizophrenia, autism and epilepsy are associated with an increased incidence of …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
mortality, but how to predict which patients are at risk and how to prevent it remain uncertain …