The thymus is an organ that is critically important to the immune system, which serves as the
body's defense mechanism, providing surveillance and protection against diverse …

The generation of a functional T cell repertoire in the thymus is mainly orchestrated by
thymic epithelial cells (TECs), which provide developing T cells with cues for their …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Motivation Increasing numbers of large scale single cell RNA-Seq projects are leading to a
data explosion, which can only be fully exploited through data integration. A number of …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Skin homeostasis is orchestrated by dozens of cell types that together direct stem cell
renewal, lineage commitment, and differentiation. Here, we use single-cell RNA sequencing …

The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

T cell development in the mouse thymus has been studied extensively, but less is known
regarding T cell development in the human thymus. We used a combination of single-cell …

Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …

The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell
development. Although in vitro biochemical assays suggest that HMG proteins can serve as …