Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

J Li, X Wang, H Zhang, X Hu, X Peng… - Medicinal Research …, 2025 - Wiley Online Library
Fenamates as classical nonsteroidal anti‐inflammatory agents are widely used for relieving
pain. Preclinical studies and epidemiological data highlight their chemo‐preventive and …

The potential preventive and therapeutic roles of NSAIDs in prostate cancer

H Maghsoudi, F Sheikhnia, P Sitarek, N Hajmalek… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer is a serious health problem for men around the world, and
it is often caused by inflammation in the prostate gland. The authors of this article explore …

[HTML][HTML] Bioavailability as Proof to Authorize the Clinical Testing of Neurodegenerative Drugs—Protocols and Advice for the FDA to Meet the ALS Act Vision

SK Niazi - International Journal of Molecular Sciences, 2024 - mdpi.com
Although decades of intensive drug discovery efforts to treat neurodegenerative disorders
(NDs) have failed, around half a million patients in more than 2000 studies continue being …

[HTML][HTML] Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized …

J Guzman‑Esquivel… - International …, 2022 - spandidos-publications.com
Mefenamic acid is a non‑steroidal anti‑inflammatory drug exhibiting a wide range of anti‑
inflammatory, antipyretic, analgesic and probable antiviral activities. The present study …

In Search for Low-Molecular-Weight Ligands of Human Serum Albumin That Affect Its Affinity for Monomeric Amyloid β Peptide

EI Deryusheva, MP Shevelyova, VA Rastrygina… - International Journal of …, 2024 - mdpi.com
An imbalance between production and excretion of amyloid β peptide (Aβ) in the brain
tissues of Alzheimer's disease (AD) patients leads to Aβ accumulation and the formation of …

Antiseizure properties of fenamate NSAIDs determined in mature human stem-cell derived neuroglial circuits

H Salmanzadeh, RF Halliwell - Frontiers in Pharmacology, 2024 - frontiersin.org
Repeated and uncontrolled seizures in epilepsy result in brain cell loss and neural
inflammation. Current anticonvulsants primarily target ion channels and receptors implicated …

[HTML][HTML] Beneficial effects of fenoprofen on cognitive impairment induced by the kindling model of epilepsy: Interaction of oxidative stress and inflammation

M Rahimi-Tesiye, H Rajabi-Maham, A Hosseini… - Brain Research …, 2025 - Elsevier
Hippocampal-dependent cognitive impairments are consequences of temporal lobe
epilepsy. This study aimed to assess the modulatory effects of fenoprofen on …

[PDF][PDF] The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer. Cancers 2023, 15, 5435

H Maghsoudi, F Sheikhnia, P Sitarek, N Hajmalek… - 2023 - academia.edu
Prostate cancer (PC) is the second most common type of cancer and the leading cause of
death among men worldwide. Preventing the progression of cancer after treatments such as …

Limited evidence of a shared genetic relationship between C-reactive protein levels and cognitive function in older UK adults of European ancestry

A Packer, A Corbett, R Arathimos, C Ballard… - Frontiers in …, 2023 - frontiersin.org
Introduction Previous studies have shown associations between cognitive function and C-
reactive protein (CRP) levels in older adults. Few studies have considered the extent to …

A Literature Review: Effects of NLRP3 Inflammasome Inhibitor on Alzheimer's Disease

MAH Muhlisin, MI Dwiyansyah, AG Sawalia… - OJS Journal of Health …, 2024 - johm.ubb.ac.id
Alzheimer is a neurodegenerative disease that is characterized by decreased cognitive
abilities and pathological changes in the brain. The prevalence of Alzheimer's disease is …