Adverse outcome pathways: opportunities, limitations and open questions
Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …
formalized, transparent and quality-controlled way, mechanistic information to apical …
[PDF][PDF] The ascending pathophysiology of cholestatic liver disease
In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …
Development of the liver: Insights into organ and tissue morphogenesis
EA Ober, FP Lemaigre - Journal of hepatology, 2018 - Elsevier
Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
D Bloch, P Diel, B Epe, M Hellwig, A Lampen… - Archives of …, 2023 - Springer
Exposure to multiple substances is a challenge for risk evaluation. Currently, there is an
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
ongoing debate if generic “mixture assessment/allocation factors”(MAF) should be …
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations
W Albrecht, F Kappenberg, T Brecklinghaus… - Archives of …, 2019 - Springer
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …
[PDF][PDF] Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood
Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic
disease. One of the early consequences of BDL in rodents is the appearance of so‐called …
disease. One of the early consequences of BDL in rodents is the appearance of so‐called …
Influence of liver fibrosis on lobular zonation
Little is known about how liver fibrosis influences lobular zonation. To address this question,
we used three mouse models of liver fibrosis, repeated CCl4 administration for 2, 6 and 12 …
we used three mouse models of liver fibrosis, repeated CCl4 administration for 2, 6 and 12 …
Multidimensional imaging of liver injury repair in mice reveals fundamental role of the ductular reaction
K Kamimoto, Y Nakano, K Kaneko, A Miyajima… - Communications …, 2020 - nature.com
Upon severe and/or chronic liver injury, ectopic emergence and expansion of atypical biliary
epithelial-like cells in the liver parenchyma, known as the ductular reaction, is typically …
epithelial-like cells in the liver parenchyma, known as the ductular reaction, is typically …
The ameliorative effect of niclosamide on bile duct ligation induced liver fibrosis via suppression of NOTCH and Wnt pathways
Highlights•Liver fibrosis was experimentally induced by bile duct ligation (BDL) in rats.•BDL
activated NOTCH and Wnt signaling pathways.•NOTCH and Wnt pathways activation led to …
activated NOTCH and Wnt signaling pathways.•NOTCH and Wnt pathways activation led to …
In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice
We describe a two-photon microscopy-based method to evaluate the in vivo systemic
transport of compounds. This method comprises imaging of the intact liver, kidney and …
transport of compounds. This method comprises imaging of the intact liver, kidney and …