The cytokine, granulocyte macrophage-colony stimulating factor (GM-CSF), was firstly
identified as being able to induce in vitro the proliferation and differentiation of bone marrow …

Inflammation is a key characteristic of kidney disease, but this immune response is two-
faced. In the acute phase of kidney injury, there is an activation of the immune cells to fight …

Background: Recent studies have established that CCR2 (CC chemokine receptor type 2)
marks proinflammatory subsets of monocytes, macrophages, and dendritic cells that …

Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Fibrosis is a pathophysiological process of wound repair that leads to the deposit of
connective tissue in the extracellular matrix. This complication is mainly associated with …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Circulating proteomic signatures of age are closely associated with aging and age-related
diseases; however, the utility of changes in secreted proteins in identifying therapeutic …

Fibrosis results from aberrant wound healing and is characterized by an accumulation of
extracellular matrix, impairing the function of an affected organ. Increased deposition of …

Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Granulocyte macrophage-colony stimulating factor (GM-CSF) was originally identified as a
growth factor for its ability to promote the proliferation and differentiation in vitro of bone …