The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Background: Cancer is the second leading cause of death in the United States. Dietary
factors account for at least 30% of all cancers in Western countries. As people do not …

Store-operated Ca2+ entry (SOCE) is the principal Ca2+ entry mechanism in nonexcitable
cells. Stromal-interaction molecule 1 (STIM1) is an endoplasmic reticulum Ca2+ sensor that …

Purpose: Acquisition of epithelial-mesenchymal transition (EMT) by primary carcinoma cells
is associated with disrupted epithelial integrity, local invasion, and ultimately metastasis …

Over 90% of all cancers are carcinomas, malignancies derived from cells of epithelial origin.
As carcinomas progress, these tumors may lose epithelial morphology and acquire …

BACKGROUND: Increasing evidence has shown that microRNAs function as oncogenes or
tumor suppressors in human malignancies, but the roles of microRNA (miR)-497 in human …

Acromegaly is characterized by sustained elevation of circulating growth hormone (GH) and
insulin-like growth factor I (IGF-I), and is clearly associated with increased morbidity and …

Exogenous application of an electric field can direct cell migration and improve wound
healing; however clinical application of the therapy remains elusive due to lack of a suitable …

Background Zoledronic acid is the most potent osteoclast inhibitor and is widely used for
advanced cancer patients with bone metastasis, but its role on cancer stem cells (CSCs) …