Understanding asthma phenotypes, endotypes, and mechanisms of disease
ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019 - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
biological network of distinct and interrelating inflammatory pathways. The term asthma is …
[HTML][HTML] Type 2 inflammation in asthma and other airway diseases
J Maspero, Y Adir, M Al-Ahmad… - ERJ open …, 2022 - Eur Respiratory Soc
Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …
COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids
Rationale: Coronavirus disease (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and …
syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and …
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13
CB Morrison, CE Edwards, KM Shaffer… - Proceedings of the …, 2022 - National Acad Sciences
Muco-obstructive lung diseases are typically associated with high risks of COVID-19
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …
Acoustic microbubble propulsion, train-like assembly and cargo transport
Achieving controlled mobility of microparticles in viscous fluids can become pivotal in
biologics, biotechniques, and biomedical applications. The self-assembly, trapping, and …
biologics, biotechniques, and biomedical applications. The self-assembly, trapping, and …
Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction
EM Dunican, BM Elicker, DS Gierada… - The Journal of …, 2018 - Am Soc Clin Investig
BACKGROUND. The link between mucus plugs and airflow obstruction has not been
established in chronic severe asthma, and the role of eosinophils and their products in …
established in chronic severe asthma, and the role of eosinophils and their products in …
Respiratory syncytial virus: infection, detection, and new options for prevention and treatment
Respiratory syncytial virus (RSV) infection is a significant cause of hospitalization of children
in North America and one of the leading causes of death of infants less than 1 year of age …
in North America and one of the leading causes of death of infants less than 1 year of age …
Type 2 inflammation in asthma—present in most, absent in many
JV Fahy - Nature Reviews Immunology, 2015 - nature.com
Asthma is one of the most common chronic immunological diseases in humans, affecting
people from childhood to old age. Progress in treating asthma has been relatively slow and …
people from childhood to old age. Progress in treating asthma has been relatively slow and …
Associations between inflammatory endotypes and clinical presentations in chronic rhinosinusitis
Background Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by
mucosal inflammation in the nose and paranasal sinuses. Inflammation in CRS is also …
mucosal inflammation in the nose and paranasal sinuses. Inflammation in CRS is also …
Eosinophilic and noneosinophilic asthma
The term “eosinophilic” asthma (EA) generally refers to the clinical inflammatory phenotype
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …
of asthma wherein a significant number of sputum, airway, and/or blood eosinophils are …