The 2015 Paediatric E uropean Network for Treatment of AIDS (PENTA) guidelines provide
practical recommendations on the management of HIV‐1 infection in children in E urope and …

Antiretroviral (ARV) therapy has been shown to achieve high therapeutic efficacy in treating
pediatric HIV disease. The delivery of affordable, child friendly, and easy to store and …

Antiretroviral therapy is the recognized treatment for human immunodeficiency virus (HIV)
infection involving several antiviral agents. Even though highly active antiretroviral therapy …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• In paediatric development, initial
estimation of the paediatric dose is obtained by extrapolation. This is usually performed …

The bioequivalence of formulations is usually evaluated in healthy adult volunteers. In our
study in 19 HIV–1–infected Ugandan children (1.8–4 years of age, weight 12 to< 15 kg) …

Background: Antiretroviral options for neonates (younger than 28 days) should be
expanded. We evaluated the pharmacokinetics, safety, and acceptability of the" 4-in-1" fixed …

Background No data on once-daily dosing of nucleoside analogues in African children
currently exist. We compared the pharmacokinetics (PK) of once-versus twice-daily …

Aim Lamivudine is used as first line therapy in HIV‐infected children. Yet, like many other
paediatric drugs, its dose rationale has been based on limited clinical data, without thorough …

Aims To characterize the pharmacokinetics of abacavir in infants, toddlers and children and
to assess the influence of covariates on drug disposition across these populations. Methods …

Over the last decade there have been dramatic changes in the management of pediatric HIV
infection. Whilst observational studies and several randomized control trials (RCTs) have …