Anti-trypanosomatid drug discovery: progress and challenges

M De Rycker, S Wyllie, D Horn, KD Read… - Nature Reviews …, 2023 - nature.com
Leishmaniasis (visceral and cutaneous), Chagas disease and human African
trypanosomiasis cause substantial death and morbidity, particularly in low-and middle …

Antileishmanial drug discovery and development: time to reset the model?

AI Olias-Molero, C de la Fuente, M Cuquerella… - Microorganisms, 2021 - mdpi.com
Leishmaniasis is a vector-borne parasitic disease caused by Leishmania species. The
disease affects humans and animals, particularly dogs, provoking cutaneous …

[HTML][HTML] Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis

LM Alcântara, TCS Ferreira, FR Gadelha… - International Journal for …, 2018 - Elsevier
Tritryps diseases are devastating parasitic neglected infections caused by Leishmania spp.,
Trypanosoma cruzi and Trypanosoma brucei subspecies. Together, these parasites affect …

[HTML][HTML] Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

D Caridha, B Vesely, K van Bocxlaer, B Arana… - International Journal for …, 2019 - Elsevier
Although there have been significant advances in the treatment of visceral leishmaniasis
(VL) and several novel compounds are currently in pre-clinical and clinical development for …

Insights into the drug screening approaches in leishmaniasis

B Gopu, P Kour, R Pandian, K Singh - International Immunopharmacology, 2023 - Elsevier
Leishmaniasis, a tropically neglected disease, is responsible for the high mortality and
morbidity ratio in poverty-stricken areas. Currently, no vaccine is available for the complete …

Of drugs and trypanosomatids: new tools and knowledge to reduce bottlenecks in drug discovery

A Bhattacharya, A Corbeil, RL do Monte-Neto… - Genes, 2020 - mdpi.com
Leishmaniasis (Leishmania species), sleeping sickness (Trypanosoma brucei), and Chagas
disease (Trypanosoma cruzi) are devastating and globally spread diseases caused by …

Targeting prolyl-tRNA synthetase to accelerate drug discovery against malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis, and coccidiosis

V Jain, M Yogavel, H Kikuchi, Y Oshima, N Hariguchi… - Structure, 2017 - cell.com
Developing anti-parasitic lead compounds that act on key vulnerabilities are necessary for
new anti-infectives. Malaria, leishmaniasis, toxoplasmosis, cryptosporidiosis and coccidiosis …

[HTML][HTML] Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron …

AHD Cataneo, F Tomiotto-Pellissier… - Biomedicine & …, 2019 - Elsevier
American cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus
Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much …

Anti-Leishmania compounds can be screened using Leishmania spp. expressing red fluorescence (tdTomato)

MGFML Cruz, AMM Santi… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
The main challenges associated with leishmaniasis chemotherapy are drug toxicity, the
possible emergence of resistant parasites, and a limited choice of therapeutic agents …

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response

EA Brettmann, JS Shaik, H Zangger… - Proceedings of the …, 2016 - National Acad Sciences
Many Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania
RNA virus 1 (LRV1), which has been associated with increased disease severity in animal …