Cinnamic acid derivatives and their biological efficacy

N Ruwizhi, BA Aderibigbe - International journal of molecular sciences, 2020 - mdpi.com
The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes
and neurological disorders, among many, has been reported. Cinnamic acid is obtained …

Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

Application of cinnamic acid in the structural modification of natural products: A review

H Deng, Q Xu, HY Guo, X Huang, F Chen, L Jin… - Phytochemistry, 2023 - Elsevier
Natural products can generally exhibit a variety of biological activities, but most show
mediocre performance in preliminary activity evaluation. Natural products often require …

A review on phyto-therapeutic approaches in alzheimer's Disease

M Sahiner, AS Yilmaz, B Gungor, N Sahiner - Journal of Functional …, 2023 - mdpi.com
Neurodegenerative diseases occur due to progressive and sometimes irreversible loss of
function and death of nerve cells. A great deal of effort is being made to understand the …

Design, synthesis and biological activity evaluation of novel carbazole-benzylpiperidine hybrids as potential anti Alzheimer agents

B Sadeghian, A Sakhteman, Z Faghih, H Nadri… - Journal of Molecular …, 2020 - Elsevier
Alzheimer's disease (AD) as the most common form of dementia in aged people, is an
intricate neurodegenerative disease. Therefore, a novel strategy so-called multi-target …

Design, Synthesis, and Cholinesterase Inhibition Assay of Coumarin‐3‐carboxamide‐N‐morpholine Hybrids as New Anti‐Alzheimer Agents

MB Tehrani, Z Rezaei, M Asadi… - Chemistry & …, 2019 - Wiley Online Library
A new series of coumarin‐3‐carboxamide‐N‐morpholine hybrids 5a–5l was designed and
synthesized as cholinesterases inhibitors. The synthetic approach for title compounds was …

Tryptamine: A privileged scaffold for the management of Alzheimer's disease

YP Singh, H Kumar - Drug Development Research, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a chronic and irreversible neurodegenerative disease
associated with aging. It is characterized by the progressive loss of memory and other …

Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

E Barresi, E Baglini, V Poggetti, J Castagnoli… - Molecules, 2024 - mdpi.com
Neurodegeneration is a gradual decay process leading to the depletion of neurons in both
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …

Progress and development of carbazole scaffold based as potential anti-alzheimer agents using MTDL approach

N Kumar, P Gupta, S Bansal - Letters in Drug Design & …, 2022 - ingentaconnect.com
Alzheimer's is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …

Synthesis of Novel Pyrimido[4,5-b] Quinolines Containing Benzyloxy and 1,2,3-Triazole Moieties by DABCO as a Basic Catalyst

S Esmaili, AR Moosavi-Zare, A Khazaei, Z Najafi - ACS omega, 2022 - ACS Publications
DABCO was used as a basic and inexpensive catalyst for the synthesis of some new
benzyloxy pyrimido [4, 5-b] quinoline derivatives and 1, 2, 3-triazole-fused pyrimido [4, 5-b] …