As one of the few cellular traits that can be quantified across the tree of life, DNA-replication
fidelity provides an excellent platform for understanding fundamental evolutionary …

Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …

Transcription is a source of genetic instability that can notably result from the formation of
genotoxic DNA: RNA hybrids, or R-loops, between the nascent mRNA and its template. Here …

Mutations are the ultimate source of all genetic variation. However, few direct estimates of
the contribution of mutation to molecular genetic variation are available. To address this …

All organisms must safeguard the integrity of their DNA to avoid deleterious consequences
of genome instability, which have been linked to human diseases such as autoimmune …

The transcriptional intermediates of RNAs fold into secondary structures with multiple
regulatory roles, yet the details of such cotranscriptional RNA folding are largely unresolved …

R-loops are evolutionarily conserved three-stranded structures that result from the formation
of stable DNA: RNA hybrids in the genome. R-loops have attracted increasing interest in …

Important genomic regions mutate less often than do other regions Skip to main content
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Mutation is the origin of all genetic variation, good and bad. The mutation process can
evolve in response to mutations, positive or negative selection, and genetic drift, but how …

Background Mutation rates vary across the genome. Many trans factors that influence
mutation rates have been identified, as have specific sequence motifs at the 1–7-bp scale …