Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in
types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O …

Protein traffic is of critical importance for normal cellular physiology. In eukaryotes, spherical
transport vesicles move proteins and lipids from one internal membrane-bound …

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers.
Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the …

Melanosomes are the specialized intracellular organelles of pigment cells devoted to the
synthesis, storage and transport of melanin pigments, which are responsible for most visible …

The KDEL receptor is a seven-transmembrane-domain protein that was first described about
20 years ago. Its well-known function is to retrotransport chaperones from the Golgi complex …

Endoplasmic reticulum (ER) chaperones (eg, calreticulin, heat shock proteins, and
isomerases) perform a multitude of functions within the ER. However, many of these …

After growth factor stimulation, kinases are activated to regulate multiple aspects of cell
physiology. Activated Src is present on Golgi membranes, but its function here remains …

Since its first visualization in 1898, the Golgi has been a topic of intense morphological
research. A typical mammalian Golgi consists of a pile of stapled cisternae, the Golgi stack …

To what extent the secretory pathway is regulated by cellular signaling is unknown. In this
study, we used RNA interference to explore the function of human kinases and …

For growth, survival, communication and homeostasis, cells transport a large number of
proteins to the plasma membrane and the extracellular medium by using the secretory …