Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of
these modifications presents formidable challenges but their determination generates …

The quantification of differences between two or more physiological states of a biological
system is among the most important but also most challenging technical tasks in proteomics …

Cell signaling mechanisms often transmit information via posttranslational protein
modifications, most importantly reversible protein phosphorylation. Here we develop and …

Cellular responses to DNA damage are mediated by a number of protein kinases, including
ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the …

The field of proteomics is built on technologies to analyze large numbers of proteins—ideally
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …

The sequencing of complete genomes provides a list that includes the proteins responsible
for cellular regulation. However, this does not immediately reveal what these proteins do …

Tyrosine kinases play a prominent role in human cancer, yet the oncogenic signaling
pathways driving cell proliferation and survival have been difficult to identify, in part because …

Post-translational modifications generate tremendous diversity, complexity and
heterogeneity of gene products, and their determination is one of the main challenges in …

The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently …

The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes.
Its oncogenic counterpart, the Bcr–Abl fusion protein, causes certain human leukaemias …