Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models

E Puighermanal, M Luna-Sánchez, A Gella… - Nature …, 2024 - nature.com
Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of
untreatable disorders known as primary mitochondrial diseases (MD). Leigh syndrome (LS) …

Biochemical, structural characterization and assessing the biological effects of cinnamon nanoparticles

Z Sabouri, N Shakour, M Sabouri… - Biotechnology and …, 2024 - Springer
The natural polyphenolic materials that cinnamon contains are well known for their different
biological applications and have a wide variety of pharmacological and therapeutic …

Anti-inflammatory, antioxidant, and WAT/BAT-Conversion stimulation induced by novel PPAR ligands: results from ex vivo and in vitro studies

L Recinella, B De Filippis, ML Libero, A Ammazzalorso… - Pharmaceuticals, 2023 - mdpi.com
Activation of peroxisome proliferator-activated receptors (PPARs) not only regulates multiple
metabolic pathways, but mediates various biological effects related to inflammation and …

Cannabinoid‐like compounds found in non‐cannabis plants exhibit antiseizure activity in genetic mouse models of drug‐resistant epilepsy

KL Yip, M Udoh, LA Sharman, T Harman… - …, 2025 - Wiley Online Library
Objective The cannabinoid cannabidiol has established antiseizure effects in drug‐resistant
epilepsies such as Dravet syndrome and Lennox–Gastaut syndrome. Amorfrutin 2, honokiol …

Effect of Cardarine on Gene Expression of Proteins Involved in Epileptogenesis in Rat Hippocampus in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy

AR Kharisova, AI Roginskaya, OE Zubareva - Journal of Evolutionary …, 2024 - Springer
During the last years, the role of astro-and microglial cells and associated
neuroinflammation in the pathogenesis of epilepsy has been extensively discussed. These …

Unveiling the shield: Troglitazone's impact on epilepsy‐induced nerve injury through ferroptosis inhibition

ZB Wang, JY Liu, SL Jiang, W Zhuo… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Epilepsy is a widespread central nervous system disorder with an estimated 50
million people affected globally. It is characterized by a bimodal incidence peak among …

Berberine Inhibited SASP-Related Inflammation through RXR/PPAR/NEDD4 Pathway in Atherosclerosis

Y Zheng, J Kou, X Gao, J Guo, Q Liu, H Ren… - The American Journal …, 2025 - World Scientific
The accumulation of aging cells significantly contributes to chronic inflammatory diseases
such as atherosclerosis. Human carotid artery single-cell sequencing has shown that large …

PPARβ/δ Agonist GW0742 Modulates Microglial and Astroglial Gene Expression in a Rat Model of Temporal Lobe Epilepsy

OE Zubareva, AR Kharisova… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The role of astroglial and microglial cells in the pathogenesis of epilepsy is currently under
active investigation. It has been proposed that the activity of these cells may be regulated by …

Network analysis reveals a role of the hippocampus in absence seizures: The effects of a cannabinoid agonist

MV Sysoeva, GD Kuznetsova, IV Sysoev, RT Ngomba… - Epilepsy Research, 2023 - Elsevier
The role of the hippocampus (Hp) in absence epileptic networks and the effect of
endocannabinoid system on this network remain enigmatic. Here, using adapted nonlinear …

Cardarin Effect on the Formation of Histopathological and Behavioral Abnormalities in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats

MR Subkhankulov, DS Sinyak, VA Guk… - Journal of Evolutionary …, 2024 - Springer
Epilepsy is a severe neuropsychological disease accompanied by the development of
spontaneous recurrent seizures (SRS) and associated behavioral disorders that are difficult …