Biological function of long non-coding RNA (LncRNA) Xist

W Wang, L Min, X Qiu, X Wu, C Liu, J Ma… - Frontiers in cell and …, 2021 - frontiersin.org
Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Transcription regulation by long non-coding RNAs: mechanisms and disease relevance

J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

The X chromosome and sex-specific effects in infectious disease susceptibility

H Schurz, M Salie, G Tromp, EG Hoal, CJ Kinnear… - Human genomics, 2019 - Springer
The X chromosome and X-linked variants have largely been ignored in genome-wide and
candidate association studies of infectious diseases due to the complexity of statistical …

Long non-coding RNAs and rheumatoid arthritis: pathogenesis and clinical implications

O Elazazy, HM Midan, RK Shahin, AE Elesawy… - … -Research and Practice, 2023 - Elsevier
Long non-coding RNAs (lncRNAs) are a class of noncoding RNAs with a length larger than
200 nucleotides that participate in various diseases and biological processes as they can …

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation

M Souyris, JE Mejía, J Chaumeil, JC Guéry - Seminars in …, 2019 - Springer
Women develop stronger immune responses than men, with positive effects on the
resistance to viral or bacterial infections but magnifying also the susceptibility to autoimmune …

The conneXion between sex and immune responses

KS Forsyth, N Jiwrajka, CD Lovell… - Nature Reviews …, 2024 - nature.com
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …

[HTML][HTML] Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases

CM Syrett, B Paneru, D Sandoval-Heglund, J Wang… - JCI insight, 2019 - ncbi.nlm.nih.gov
Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects
women and is driven by autoreactive T cell–mediated inflammation. It is known that …

Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity

M Pujantell, M Altfeld - Frontiers in immunology, 2022 - frontiersin.org
The immune system protects us from pathogens, such as viruses. Antiviral immune
mechanisms aim to limit viral replication, and must maintain immunological homeostasis to …

Escape from X chromosome inactivation and the female predominance in autoimmune diseases

A Youness, CH Miquel, JC Guéry - International journal of molecular …, 2021 - mdpi.com
Women represent 80% of people affected by autoimmune diseases. Although, many studies
have demonstrated a role for sex hormone receptor signaling, particularly estrogens, in the …

Besides pathology: long non-coding RNA in cell and tissue homeostasis

A Salviano-Silva, SC Lobo-Alves, RC Almeida… - Non-coding RNA, 2018 - mdpi.com
A significant proportion of mammalian genomes corresponds to genes that transcribe long
non-coding RNAs (lncRNAs). Throughout the last decade, the number of studies concerning …