CD40 is a TNF receptor superfamily member expressed on both immune and non-immune
cells. Interactions between B cell-expressed CD40 and its binding partner, CD40L …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

In many ways, atherosclerosis is a chronic inflammatory disorder and this issue is confirmed
by recent investigations of that have focused on inflammation, providing new insight into …

In this commentary, we have suggested that the fibroblast should be considered a sentinel
cell. This concept is based on the fibroblast's ability to function both as a structural element …

Integrating basic and clinical research on the biophysical and physiological functions of
pulmonary surfactants, this practical reference presents thorough, cutting-edge coverage on …

Mesenchymal stem cell (MSC) therapy offers great potential for treatment of disease through
the multifunctional and responsive ability of these cells. In numerous contexts, MSC have …

The capacity of fibroblasts to produce and organize the extracellular matrix and to
communicate with other cells makes them a central component of tissue biology. Even so …

Tissue fibrosis can lead to significant organ dysfunction and resulting patient morbidity and
mortality. Unfortunately, the therapeutic repertoire is currently limited, nonspecific, and …

Introduction Cigarette smoke is a profound pro-inflammatory stimulus that contributes to
acute lung injuries and to chronic lung disease including COPD (emphysema and chronic …

Fibroblasts represent a dynamic population of cells, exhibiting functional heterogeneity
within and among tissues. Fibroblast heterogeneity also results from phenotypic differences …