[HTML][HTML] Noncoding RNA therapeutics—challenges and potential solutions
M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
[HTML][HTML] The role of non-coding RNAs in oncology
FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …
[HTML][HTML] Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …
of DNA sequence. It requires interactions cohesively with various enzymes and other …
[HTML][HTML] Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers
N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …
[HTML][HTML] Long non-coding RNAs: from disease code to drug role
Y Chen, Z Li, X Chen, S Zhang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Enormous studies have corroborated that long non-coding RNAs (lncRNAs) extensively
participate in crucial physiological processes such as metabolism and immunity, and are …
participate in crucial physiological processes such as metabolism and immunity, and are …
[HTML][HTML] MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
been considered as 'junk'for a long time, non-coding RNAs are now well established as …
[HTML][HTML] Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue
RS Zhou, EX Zhang, QF Sun, ZJ Ye, JW Liu, DH Zhou… - BMC cancer, 2019 - Springer
Background Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can
bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby …
bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby …
LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy
Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8+ T cells and
triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs …
triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs …
The RNA Atlas expands the catalog of human non-coding RNAs
Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are
derived almost exclusively from small and polyadenylated RNAs. Here we present a more …
derived almost exclusively from small and polyadenylated RNAs. Here we present a more …
[HTML][HTML] Non-coding RNAs in cancer: Platforms and strategies for investigating the genomic “dark matter”
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …
malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are …