Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

The endoplasmic reticulum (ER) is the largest organelle of the cell, composed of a
continuous network of sheets and tubules, and is involved in protein, calcium (Ca 2+), and …

The climate change induced global warming, and in particular the increased frequency and
intensity of heat waves, have been linked to health problems. Among them, scientific works …

Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies
that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for …

Endoplasmic reticulum (ER) stress has been identified as a primary factor involved in brain
ischemia-reperfusion injury progression. p21-activated kinase 2 (Pak2) is a novel ER …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease
characterized by the degeneration of motor neurons. Mutations in the cyclin F (CCNF) and …

Protein aggregation plays key roles in age-related degenerative diseases, but how different
proteins coalesce to form inclusions that vary in composition, morphology, molecular …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
degeneration of motor neurons. Between 12 and 20% of inherited cases and approximately …

Chronological age causes structural and functional vascular deterioration and is a well‐
established risk factor for the development of cardiovascular diseases, leading to more than …