In the human genome more than 400 genes encode ion channels, which are
transmembrane proteins mediating ion fluxes across membranes. Being expressed in all …

Sudden cardiac death (SCD) is a devastating and all too common result of both acquired
and genetic heart diseases. The profound sadness endured by families is compounded by …

Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …

Background: Variants in ion channel genes have classically been studied in low throughput
by patch clamping. Deep mutational scanning is a complementary approach that can …

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic
cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field …

The Scripps molecular autopsy study seeks to incorporate genetic testing into the
postmortem examination of cases of sudden death in the young (< 45 years old). Here, we …

Background: A systems biology approach to cardiac physiology requires a comprehensive
representation of how coordinated processes operate in the heart, as well as the ability to …

Sudden cardiac death (SCD) is defined as the unexpected death without an obvious
noncardiac cause that occurs within 1 h of witnessed symptom onset (established SCD) or …

Short QT syndrome is a malignant cardiac disease characterized by the presence of
ventricular tachyarrhythmias leading to syncope and sudden cardiac death. Currently …

Context: The congenital long QT syndrome (LQTS) is an inherited channelopathy known for
its electrocardiographic manifestations of QT prolongation and its hallmark arrhythmia …