Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The classic understanding of molecular disease-mechanisms is largely based on protein-
centric models. During the past decade however, genetic studies have identified numerous …

The human genome is pervasively transcribed and yet only a small fraction of these RNAs
(less than 2%) are known to code for proteins. The vast majority of the RNAs are classified …

Transcription of the proto-oncogene SPHK1 is regulated by KHPS1, an antisense RNA that
activates SPHK1 expression by forming a triple-helical RNA-DNA-DNA structure at the …

RNA can directly bind to purine-rich DNA via Hoogsteen base pairing, forming a DNA: RNA
triple helical structure that anchors the RNA to specific sequences and allows guiding of …

Exosomal lncRNAs secreted by cancer cells can serve as potential biomarkers in the
diagnosis and prognosis of various tumours. Here, we are committed to explore the …

Background Super enhancers (SE) play pivotal roles in cell identity and diseases occur
including tumorigenesis. The depletion of SE‐associated lncRNA transcripts, also known as …

Thomas Kuhn described the progress of science as comprising occasional paradigm shifts
separated by interludes of 'normal science'. The paradigm that has held sway since the …

Simple Summary Long non-coding RNAs (lncRNAs) are a large class of RNA molecules
known to regulate the expression of genes. Although expressed in a highly tissue-specific …