The UFM1 system: Working principles, cellular functions, and pathophysiology
Summary Ubiquitin-fold modifier 1 (UFM1) is a ubiquitin-like protein covalently conjugated
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …
with intracellular proteins through UFMylation, a process similar to ubiquitylation. Growing …
Decrypting UFMylation: how proteins are modified with UFM1
Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also
covalently modify target proteins. To date, less is known about UBLs than Ub and even less …
covalently modify target proteins. To date, less is known about UBLs than Ub and even less …
A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-resident UFMylation
JR Liang, E Lingeman, T Luong, S Ahmed, M Muhar… - Cell, 2020 - cell.com
Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …
MRE11 UFMylation promotes ATM activation
Z Wang, Y Gong, B Peng, R Shi, D Fan… - Nucleic acids …, 2019 - academic.oup.com
A proper DNA damage response (DDR) is essential to maintain genome integrity and
prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion …
prevent tumorigenesis. DNA double-strand breaks (DSBs) are the most toxic DNA lesion …
A guide to UFMylation, an emerging posttranslational modification
Ubiquitin Fold Modifier‐1 (UFM1) is a ubiquitin‐like modifier (UBL) that is posttranslationally
attached to lysine residues on substrates via a dedicated system of enzymes conserved in …
attached to lysine residues on substrates via a dedicated system of enzymes conserved in …
Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays
Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …
development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated …
CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development
Protein modification by ubiquitin and ubiquitin-like proteins (UBLs) regulates numerous
biological functions. The UFM1 system, a novel UBL conjugation system, is implicated in …
biological functions. The UFM1 system, a novel UBL conjugation system, is implicated in …
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation
Y Cai, G Zhu, S Liu, Z Pan, M Quintero, CJ Poole, C Lu… - Cell Discovery, 2019 - nature.com
Intestinal exocrine secretory cells, including Paneth and goblet cells, have a pivotal role in
intestinal barrier function and mucosal immunity. Dysfunction of these cells may lead to the …
intestinal barrier function and mucosal immunity. Dysfunction of these cells may lead to the …
Stress-Regulation of SUMO conjugation and of other Ubiquitin‐Like Modifiers
D Ilic, HM Magnussen, M Tirard - Seminars in cell & developmental biology, 2022 - Elsevier
Stress is unavoidable and essential to cellular and organismal evolution and failure to adapt
or restore homeostasis can lead to severe diseases or even death. At the cellular level …
or restore homeostasis can lead to severe diseases or even death. At the cellular level …
Highly specialized ubiquitin-like modifications: shedding light into the UFM1 enigma
KF Witting, MPC Mulder - Biomolecules, 2021 - mdpi.com
Post-translational modification with Ubiquitin-like proteins represents a complex signaling
language regulating virtually every cellular process. Among these post-translational …
language regulating virtually every cellular process. Among these post-translational …