Drug Resistance in Toxoplasma gondii

M Montazeri, S Mehrzadi, M Sharif, S Sarvi… - Frontiers in …, 2018 - frontiersin.org
Toxoplasma gondii (T. gondii) is a global protozoan parasite infecting up to one-third of the
world population. Pyrimethamine (PYR) and sulfadiazine (SDZ) are the most widely used …

[PDF][PDF] Fluoroquinolone antibacterials: a review on chemistry, microbiology and therapeutic prospects

PC Sharma, A Jain, S Jain - Acta Pol Pharm, 2009 - ptfarm.pl
Fluoroquinolones are one of the most promising and vigorously pursued areas of
contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They …

Quinolone-3-diarylethers: a new class of antimalarial drug

A Nilsen, AN LaCrue, KL White, IP Forquer… - Science translational …, 2013 - science.org
The goal for developing new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …

Comparative QSARs for antimalarial endochins: Importance of descriptor-thinning and noise reduction prior to feature selection

PK Ojha, K Roy - Chemometrics and Intelligent Laboratory Systems, 2011 - Elsevier
The emergence of multidrug resistance of the currently available antimalarial drugs has led
to the need of the discovery and development of new antimalarial compounds. In the present …

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

Y Li, S Shah-Simpson, K Okrah, AT Belew… - PLoS …, 2016 - journals.plos.org
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …

Mitochondrial evolution and functions in malaria parasites

AB Vaidya, MW Mather - Annual review of microbiology, 2009 - annualreviews.org
Mitochondria in malaria parasites have some unusual evolutionary and functional features.
The drastic reduction in the size of their mitochondrial genome, encoding just three proteins …

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

JS Doggett, A Nilsen, I Forquer… - Proceedings of the …, 2012 - National Acad Sciences
Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating
ocular and central nervous system disease. We show that the endochin-like quinolone …

Antimalarial pharmacology and therapeutics of atovaquone

GL Nixon, DM Moss, AE Shone… - Journal of …, 2013 - academic.oup.com
Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating
children and adults with uncomplicated malaria or as chemoprophylaxis for preventing …

Antiplasmodial and antimalarial activities of quinolone derivatives: An overview

YL Fan, XW Cheng, JB Wu, M Liu, FZ Zhang… - European Journal of …, 2018 - Elsevier
Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …

Metalloantimalarials

PF Salas, C Herrmann, C Orvig - Chemical reviews, 2013 - ACS Publications
Malaria is a worldwide neglected infectious disease that, despite decades of research
invested in its prevention and treatment, remains one of the main causes of mortality and …