Drug Resistance in Toxoplasma gondii
M Montazeri, S Mehrzadi, M Sharif, S Sarvi… - Frontiers in …, 2018 - frontiersin.org
Toxoplasma gondii (T. gondii) is a global protozoan parasite infecting up to one-third of the
world population. Pyrimethamine (PYR) and sulfadiazine (SDZ) are the most widely used …
world population. Pyrimethamine (PYR) and sulfadiazine (SDZ) are the most widely used …
[PDF][PDF] Fluoroquinolone antibacterials: a review on chemistry, microbiology and therapeutic prospects
PC Sharma, A Jain, S Jain - Acta Pol Pharm, 2009 - ptfarm.pl
Fluoroquinolones are one of the most promising and vigorously pursued areas of
contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They …
contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They …
Quinolone-3-diarylethers: a new class of antimalarial drug
A Nilsen, AN LaCrue, KL White, IP Forquer… - Science translational …, 2013 - science.org
The goal for developing new antimalarial drugs is to find a molecule that can target multiple
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …
stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of …
Comparative QSARs for antimalarial endochins: Importance of descriptor-thinning and noise reduction prior to feature selection
The emergence of multidrug resistance of the currently available antimalarial drugs has led
to the need of the discovery and development of new antimalarial compounds. In the present …
to the need of the discovery and development of new antimalarial compounds. In the present …
Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
Y Li, S Shah-Simpson, K Okrah, AT Belew… - PLoS …, 2016 - journals.plos.org
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …
Mitochondrial evolution and functions in malaria parasites
Mitochondria in malaria parasites have some unusual evolutionary and functional features.
The drastic reduction in the size of their mitochondrial genome, encoding just three proteins …
The drastic reduction in the size of their mitochondrial genome, encoding just three proteins …
Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis
JS Doggett, A Nilsen, I Forquer… - Proceedings of the …, 2012 - National Acad Sciences
Toxoplasma gondii is a widely distributed protozoan pathogen that causes devastating
ocular and central nervous system disease. We show that the endochin-like quinolone …
ocular and central nervous system disease. We show that the endochin-like quinolone …
Antimalarial pharmacology and therapeutics of atovaquone
GL Nixon, DM Moss, AE Shone… - Journal of …, 2013 - academic.oup.com
Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating
children and adults with uncomplicated malaria or as chemoprophylaxis for preventing …
children and adults with uncomplicated malaria or as chemoprophylaxis for preventing …
Antiplasmodial and antimalarial activities of quinolone derivatives: An overview
YL Fan, XW Cheng, JB Wu, M Liu, FZ Zhang… - European Journal of …, 2018 - Elsevier
Malaria remains one of the most deadly infectious diseases globally. Considering the
growing spread of resistance, development of new and effective antimalarials remains an …
growing spread of resistance, development of new and effective antimalarials remains an …