Solid tumours are an enormous cancer burden and a major therapeutic challenge. The
cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Glioblastoma (GBM) is a cancer comprised of morphologically, genetically, and
phenotypically diverse cells. However, an understanding of the functional significance of …

Human brain tumors appear to have a hierarchical cellular organization suggestive of a
stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines …

The investigation and study of cancer stem cells (CSCs) have received enormous attention
over the past 5 to 10 years but remain topics of considerable controversy. Opinions about …

Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals
on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in …

An essential step for therapeutic and research applications of stem cells is the ability to
differentiate them into specific cell types. Endodermal cell derivatives, including lung, liver …

Cancer has long been viewed as an exclusively genetic disorder. The model of
carcinogenesis, postulated by Nowell and Vogelstein, describes the formation of a tumor by …

Purpose: Cancer stem cells (CSC) are thought to represent the population of tumorigenic
cells responsible for tumor development. The stem cell antigen CD133 identifies such a …

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine that acts as a
neurotransmitter in the central nervous system, local mediator in the gut and vasoactive …