Natural products as protective agents for male fertility

RVL Martins, AMS Silva, AP Duarte, S Socorro… - BioChem, 2021 - mdpi.com
The male reproductive system is highly susceptible to noxious influences, such as oxidative
stress, inflammation, drugs, and even diseases that can induce germ cell damage and …

Natural products against cisplatin‐induced male reproductive toxicity: A comprehensive review

A Rahimi, F Asadi, M Rezghi, S Kazemi… - … of Biochemical and …, 2022 - Wiley Online Library
Cisplatin is widely used as one of the most effective anticancer agents in the treatment of
some neoplasms. Reproductive toxicity is the most common outcome associated with …

Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways

EHM Hassanein, BA Abdel-Wahab, FEM Ali… - … Science and Pollution …, 2021 - Springer
Testicular damage has been described as a common side effect of cisplatin (CDDP), which
limits its clinical uses. Since oxidative injury and inflammatory response are the most …

Histochemical and histomorphological evidence of the modulating role of 1-isothiocyanate-4-methyl sulfonyl butane on cisplatin-induced testicular-pituitary axis …

SA Adelakun, OW Akintunde, B Ogunlade… - Morphologie, 2023 - Elsevier
Background This study examine the histochemical and histomorphological effect of 1-
isothiocyanato-4-methyl sulfonyl butane (SFN) on cisplatin (CP) induced testicular alteration …

[HTML][HTML] Ameliorating potential and fertility enhancing activities of nutritional dietary supplementation of D-Ribose–l-Cysteine in cisplatin induced …

SA Adelakun, B Ogunlade, KA Iteire, OA Adedotun - Metabolism Open, 2021 - Elsevier
Background Cisplatin (CN) is considered as a cytotoxic agent and DNA synthesis inhibitor.
D-Ribose-l-Cysteine (DRLC) is an active ingredient of riboceine, help cells to produce …

[HTML][HTML] Protective effect of nutritional supplementation of zinc-sulfate against cisplatin-induced spermatogonial and testicular dysfunctions in adult male Sprague …

SA Adelakun, B Ogunlade, OP Fidelis… - Endocrine and Metabolic …, 2022 - Elsevier
Zinc (Zn) has proven to play a key role in spermatogenesis. The present study focused on
the nutritional supplementation of Zn against cisplatin (CP)-induced spermatogonial and …

[HTML][HTML] Excessive Caffeine Intake inhibits steroidogenesis, folliculogenesis and disrupts utero-ovarian tissue histomorphology integrity in experimental rats, and …

SA Adelakun, B Ogunlade, JA Aniah, BP Akwu… - Food Chemistry …, 2024 - Elsevier
Polycystic ovarian syndrome (PCOS) is characterized by anovulation and
hyperandrogenism symptoms. Caffeine is popularly consumed and it is a legal psychoactive …

[HTML][HTML] Efficacy of quercetin-sensitized cisplatin against N-nitroso-N-methylurea induced testicular carcinogenesis in wistar rats

HHGM El-Diasty, H El-Sayyad, S Refat… - Asian Pacific Journal …, 2021 - ncbi.nlm.nih.gov
Background: Testicular cancer is a public health problem. The goal of this study was to
demonstrate the efficacy of quercetin treatment on N-nitroso-N-methyl-urea (MNU)-induced …

[HTML][HTML] Melatonin exhibits partial protective effects against gemcitabine-and cisplatin-induced kidney and reproductive injuries in mice

SC Wang, HC Hsu, YC Chang, CY Yu, CT Liu… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Cisplatin has the potential to cause kidney and reproductive organ injuries, prompting the
search for protective agents against cisplatin-induced toxicity. Melatonin, an antioxidant …

Anti-diarrhoeal activity of aqueous extract of Cochlospermum planchonii (Hook Fx. Planch) leaves in female Wistar rats

MT Yakubu, OD Amoniyan, MO Mohammed… - Journal of Medicinal …, 2020 - journals.co.za
Background: The folkloric use of Cochlospermum planchonii is yet to be substantiated with
scientific evidence. Aim: The aqueous extract of C. planchonii leaves was evaluated for anti …