Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

The transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2) has been mainly
investigated as a regulator of redox homeostasis. However, research over the past years …

Atherosclerosis is the underlying reason for nearly all causes of coronary artery disease and
peripheral arterial disease and many cases of stroke. Atherosclerosis is a systemic …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Aims Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood
cholesterol levels and chronic inflammation. Low-density lipoprotein receptors (LDLR) play …

The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits
observed in patients that have followed PCSK9-targeted therapies. The impact of these …

Coronary artery disease, the leading cause of death in the developed and developing
countries, is prevalent in diabetes mellitus with 68% cardiovascular disease (CVD)-related …

Chronic inflammation and oxidative stress are common and co-substantial pathological
processes accompanying and contributing to cancers. Numerous epidemiological studies …

Vascular smooth muscle cells (SMCs) are the major cell type within blood vessels. SMCs
exhibit low rates of proliferation, migration, and apoptosis in normal blood vessels. However …