Compartmentalization is an essential process that allows cells to organize, creating
controlled microenvironments for specific metabolic pathways. Therefore, this allows the …

Mycobacterium tuberculosis has evolved various mechanisms by which the bacterium can
maintain homeostasis under numerous environmental assaults generated by the host …

Ferritins and bacterioferritins are iron storage proteins that represent key players in iron
homeostasis. Several organisms possess both forms of ferritins, however, their relative …

The self-assembled ferritin nanocages, nature's solution to iron toxicity and its low solubility,
scavenge free iron to synthesize hydrated ferric oxyhydroxide mineral inside their central …

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), faces iron
scarcity within the host due to immune defenses. This review explores the importance of iron …

The uptake and utilization of iron remains critical for the survival/virulence of the
host/pathogens in spite of the limitations (low bioavailability/high toxicity) associated with …

Mycobacterium tuberculosis (Mtb) expresses heme binding protein nanocages,
bacterioferritin A (BfrA), along with nonheme bacterioferritin B (BfrB). BfrA is unique to …

Ferritins are a large family of iron storage proteins, which are used by bacteria and other
organisms to avoid iron toxicity and as a safe iron source in the cytosol. Agrobacterium …

Dysregulated iron metabolism is reported in tuberculosis patients; therefore, it represents an
opportunity for developing host-directed therapeutics. This study monitored the …

Iron is a critical element used for survival of both host and pathogens. Tuberculosis patients
show dysregulated iron metabolism and provide an opportunity for developing host directed …