Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
PI3K isoforms in cell signalling and vesicle trafficking
B Bilanges, Y Posor, B Vanhaesebroeck - Nature reviews Molecular …, 2019 - nature.com
PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Harnessing the potential beneficial effects of kinase signalling through the generation of
direct kinase activators remains an underexplored area of drug development,,,–. This also …
direct kinase activators remains an underexplored area of drug development,,,–. This also …
Molecular mechanism of fast endophilin-mediated endocytosis
A Casamento, E Boucrot - Biochemical Journal, 2020 - portlandpress.com
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-
mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional …
mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
An excitable Ras/PI3K/ERK signaling network controls migration and oncogenic transformation in epithelial cells
Summary The Ras/PI3K/extracellular signal-regulated kinases (ERK) signaling network
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …
plays fundamental roles in cell growth, survival, and migration and is frequently activated in …
An update on genetically encoded lipid biosensors
GRV Hammond, MMC Ricci… - Molecular biology of …, 2022 - Am Soc Cell Biol
Specific lipid species play central roles in cell biology. Their presence or enrichment in
individual membranes can control properties or direct protein localization and/or activity …
individual membranes can control properties or direct protein localization and/or activity …
Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane
JP Zewe, AM Miller, S Sangappa, RC Wills… - Journal of Cell …, 2020 - rupress.org
The polyphosphoinositides (PPIn) are central regulatory lipids that direct membrane function
in eukaryotic cells. Understanding how their synthesis is regulated is crucial to revealing …
in eukaryotic cells. Understanding how their synthesis is regulated is crucial to revealing …
LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes
Genetic variation in LRRK2 associates with the susceptibility to Parkinson's disease, Crohn's
disease, and mycobacteria infection. High expression of LRRK2 and its substrate Rab10 …
disease, and mycobacteria infection. High expression of LRRK2 and its substrate Rab10 …
[HTML][HTML] PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes
J Pacheco, AC Cassidy, JP Zewe, RC Wills… - Journal of Cell …, 2022 - rupress.org
The lipid phosphatidyl-D-myo-inositol-4, 5-bis phosphate [PI (4, 5) P2] is a master regulator
of plasma membrane (PM) function. Its effector proteins regulate transport, signaling, and …
of plasma membrane (PM) function. Its effector proteins regulate transport, signaling, and …