The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Y Chen, C Qin, J Huang, X Tang, C Liu… - Cell …, 2020 - Wiley Online Library
Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Oxidative stress in traumatic brain injury

A Fesharaki-Zadeh - International journal of molecular sciences, 2022 - mdpi.com
Traumatic Brain Injury (TBI) remains a major cause of disability worldwide. It involves a
complex neurometabolic cascade, including oxidative stress. The products of this …

Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury

B Huang, T Tang, SH Chen, H Li, ZJ Sun… - Nature …, 2023 - nature.com
The blood-brain barrier breakdown, as a prominent feature after traumatic brain injury,
always triggers a cascade of biochemical events like inflammatory response and free radical …

The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

NADPH oxidase in brain injury and neurodegenerative disorders

MW Ma, J Wang, Q Zhang, R Wang… - Molecular …, 2017 - Springer
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

A review of the molecular mechanisms of traumatic brain injury

AA Ladak, SA Enam, MT Ibrahim - World neurosurgery, 2019 - Elsevier
Traumatic brain injury (TBI) refers to any insult to the brain resulting in primary (direct) and
secondary (indirect) damage to the brain parenchyma. Secondary damage is often linked to …

Brain tissue responses to neural implants impact signal sensitivity and intervention strategies

TDY Kozai, AS Jaquins-Gerstl… - ACS chemical …, 2015 - ACS Publications
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Mechanisms of blood–brain barrier dysfunction in traumatic brain injury

A Cash, MH Theus - International journal of molecular sciences, 2020 - mdpi.com
Traumatic brain injuries (TBIs) account for the majority of injury-related deaths in the United
States with roughly two million TBIs occurring annually. Due to the spectrum of severity and …

Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

WT O'Brien, L Pham, GF Symons, M Monif… - Journal of …, 2020 - Springer
There is a great clinical need to identify the underlying mechanisms, as well as related
biomarkers, and treatment targets, for traumatic brain injury (TBI). Neuroinflammation is a …