In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

In this review, we summarize current knowledge of perhaps one of the most intriguing
phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This …

Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid
peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular …

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …

Peroxisomes are essential metabolic organelles, well known for their roles in the
metabolism of complex lipids and reactive ionic species. In the past 10 years, peroxisomes …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

Mitochondria sense both biochemical and energetic input in addition to communicating
signals regarding the energetic state of the cell. Increasingly, these signaling organelles are …

Membrane contact sites between organelles are essential for maintaining cellular
homeostasis, which requires the continuous exchange of signaling molecules, ions …

Impairments in neural lysosomal-and autophagic-mediated degradation of cellular debris
contribute to neuritic dystrophy and synaptic loss. While these are well-characterized …