Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous
system that preferentially targets the optic nerves and spinal cord. The clinical presentation …

Objective The aim of this work was to determine whether atrophy of specific retinal layers
and brain substructures are associated over time, in order to further validate the utility of …

Deep neural networks have been successfully applied to medical image analysis tasks like
segmentation and synthesis. However, even if a network is trained on a large dataset from …

Optical coherence tomography (OCT) has proven to be an essential imaging modality for
ophthalmology and is proving to be very important in neurology. OCT enables high …

Background: Retinal optical coherence tomography (OCT) permits quantification of retinal
layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS) …

Post-mortem ganglion cell dropout has been observed in multiple sclerosis; however,
longitudinal in vivo assessment of retinal neuronal layers following acute optic neuritis …

Visual impairment is a key manifestation of multiple sclerosis. Acute optic neuritis is a
common, often presenting manifestation, but visual deficits and structural loss of retinal …

PURPOSE: We used high-resolution spectral-domain optical coherence tomography (SD-
OCT) with retinal segmentation to determine how ganglion cell loss relates to history of …

Objective: To develop consensus recommendations for reporting of quantitative optical
coherence tomography (OCT) study results. Methods: A panel of experienced OCT …