Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
Cryo-EM structure of alpha-synuclein fibrils
Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …
Cell biology and pathophysiology of α-synuclein
α-Synuclein is an abundant neuronal protein that is highly enriched in presynaptic nerve
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
terminals. Genetics and neuropathology studies link α-synuclein to Parkinson's disease (PD) …
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus,
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
which forms an amphipathic alpha-helix upon membrane interaction. Here we show that …
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Abstract α-Synuclein (α-syn) is a 140-residue intrinsically disordered protein that is involved
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …
in neuronal and synaptic vesicle plasticity, but its aggregation to form amyloid fibrils is the …
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
KC Luk, VM Kehm, B Zhang, P O'Brien… - Journal of Experimental …, 2012 - rupress.org
The accumulation of misfolded proteins is a fundamental pathogenic process in
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …
neurodegenerative diseases. However, the factors that trigger aggregation of α-Synuclein (α …
α-Synuclein promotes SNARE-complex assembly in vivo and in vitro
Presynaptic nerve terminals release neurotransmitters repeatedly, often at high frequency,
and in relative isolation from neuronal cell bodies. Repeated release requires cycles of …
and in relative isolation from neuronal cell bodies. Repeated release requires cycles of …
Alpha-synuclein biology in Lewy body diseases
WS Kim, K Kågedal, GM Halliday - Alzheimer's research & therapy, 2014 - Springer
Abstract α-Synuclein is an abundantly expressed neuronal protein that is at the center of
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …
focus in understanding a group of neurodegenerative disorders called α-synucleinopathies …
What genetics tells us about the causes and mechanisms of Parkinson's disease
O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …