Abstract Disease Overview Chronic myelomonocytic leukemia (CMML) is a clonal
hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes …

Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by
dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of …

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …

Abstract Purpose: TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates
antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I …

We conducted a phase I clinical trial of H3B-8800, an oral small molecule that binds Splicing
Factor 3B1 (SF3B1), in patients with MDS, CMML, or AML. Among 84 enrolled patients (42 …

Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative
neoplasm with variable clinical course. To predict the clinical outcome, we previously …

Background Pevonedistat is a first-in-class, small molecular inhibitor of NEDD8-activating
enzyme that has clinical activity in acute myeloid leukemia (AML) and myelodysplastic …

Chronic myelomonocytic leukemia (CMML) is a disease of the elderly, and by far the most
frequent overlap myelodysplastic/myeloproliferative neoplasm in adults. Aside from the …

Since last two decades, the major cancer research has focused on understanding the
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …

PURPOSE Colony-stimulating factor-3 receptor (CSF3R)-T618I is a recurrent activating
mutation in chronic neutrophilic leukemia (CNL) and to a lesser extent in atypical chronic …