Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …

Myriad genetic and epigenetic alterations are required to drive normal cells toward
malignant transformation. These somatic events commandeer many signaling pathways that …

Telomerase is a ribonucleoprotein (RNP) complex that synthesizes telomere repeats in
tissue progenitor cells and cancer cells. Active human telomerase consists of at least three …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

Recruitment to telomeres is a pivotal step in the function and regulation of human
telomerase; however, the molecular basis for recruitment is not known. Here, we have …

Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding
RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as …

Dyskeratosis congenita (DC) is a genetic disorder of defective tissue maintenance and
cancer predisposition caused by short telomeres and impaired stem cell function …

Chromosome end protection is essential to protect genome integrity. Telomeres, tracts of
repetitive DNA sequence and associated proteins located at the chromosomal terminus …