Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

Background The relationship between the systemic immune inflammatory index (SII) and the
prognosis of hypertensive patients is unclear. This study aims to explore the association of …

The mosaic theory of hypertension was advocated by Irvine Page~ 80 years ago and
suggested that hypertension resulted from the close interactions of different causes …

Several clinical and large population studies indicate that women are more salt-sensitive
than men, yet the precise mechanisms by which the sexually dimorphic onset manifests …

BACKGROUND: Inflammation plays a critical role in the development of hypertension and
vascular remodeling. Resolvin E1 (RvE1), as one of the specialized proresolving lipid …

Most hypertensive cases are primary and heavily associated with modifiable risk factors like
salt intake. Evidence suggests that even small reductions in salt consumption reduce blood …

The prevention of cardiac life-threatening ventricular fibrillation and stroke-provoking atrial
fibrillation remains a serious global clinical issue, with ongoing need for novel approaches …

Background: Chronic renal inflammation has been widely recognized as a major promoter of
several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL …

Emerging evidence has supported a role of inflammation and immunity in the genesis of
hypertension. In humans and experimental models of hypertension, cells of the innate and …