Simple Summary Despite breakthroughs in medicine, cancer remains one of the most feared
diseases. Traditionally, chemotherapies have been the treatment of choice. However …

NAMI-A ((ImH)[trans-RuCl4 (dmso-S)(Im)], Im= imidazole) and KP1019/1339
(KP1019=(IndH)[trans-RuCl4 (Ind) 2], Ind= indazole; KP1339= Na [trans-RuCl4 (Ind) 2]) are …

The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …

As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …

Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality.
Although 5 year survival rate for patients at the early stage of CRC (stages I and II) is above …

Abstract Purpose: NAMI-A {H2Im [trans-RuCl4 (DMSO) HIm] or imidazolium-trans-DMSO-
imidazole-tetrachlororuthenate} is a novel ruthenium-containing compound that has …

Due to the increasing impact of cancer on worldwide mortality, more and more attention is
being devoted to the investigation of novel anticancer strategies. Among these …

Since the discovery of cis-platinum, many transition metal complexes have been
synthesized and assayed for antineoplastic activity. In recent years, ruthenium-based …

The antitumor activity of the organometallic ruthenium (II)− arene complexes, RuCl2 (η6-
arene)(PTA),(arene= p-cymene, toluene, benzene, benzo-15-crown-5, 1-ethylbenzene-2, 3 …

Cancer is one of the major cases of death in the world. Current treatment of cancer is limited
to surgery, radiotherapy, and the use of cytotoxic agents, despite their well known side …