The endocytosis mechanism is a complicated system that is essential for cell signaling and
survival. Megalin, a membrane-associated endocytic receptor, and its related proteins such …

Membranous nephropathy (MN) is a renal-limited non-inflammatory autoimmune disease in
the glomerulus, which is the second or third main cause of end-stage kidney diseases in …

Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …

Membranous nephropathy is a noninflammatory autoimmune disease of the kidney
glomerulus, characterized by the formation of immune deposits, complement-mediated …

Since the outbreak of COVID-19 disease, a bidirectional interaction between kidney disease
and the progression of COVID-19 has been demonstrated. Kidney disease is an …

The discovery of anti-podocyte antibodies in primary membranous nephropathy (MN) has
revolutionized our approach toward the diagnosis and treatment of this disease. Evaluation …

Fibrotic diseases affect multiple organs and are associated with morbidity and mortality. To
examine organ-specific and shared biologic mechanisms that underlie fibrosis in different …

The identification of the major target antigen phospholipase A2 receptor (PLA2R) in the
majority of primary (idiopathic) cases of membranous nephropathy (MN) has been followed …

IgG4-related kidney disease (IgG4-RKD) encompasses all forms of kidney disease that are
part of IgG4-related disease (IgG4-RD). First recognized as IgG4-related tubulointerstitial …

Background Thrombospondin type 1 domain–containing 7A (THSD7A) has been identified
as a pathogenic autoantigen in membranous nephropathy (MN). However, the THSD7A …