Proteins and transcriptional dysregulation of the brain extracellular matrix in Parkinson's disease: a systematic review

WA Rike, S Stern - International Journal of Molecular Sciences, 2023 - mdpi.com
The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …

From genomics to omics landscapes of Parkinson's disease: revealing the molecular mechanisms

S Redenšek, V Dolžan, T Kunej - Omics: a journal of integrative …, 2018 - liebertpub.com
Molecular mechanisms of Parkinson's disease (PD) have already been investigated in
various different omics landscapes. We reviewed the literature about different omics …

Neuroprotective effects of cannabidiol on dopaminergic neurodegeneration and α-synuclein accumulation in C. elegans models of Parkinson's disease

F Muhammad, Y Liu, N Wang, L Zhao, Y Zhou, H Yang… - Neurotoxicology, 2022 - Elsevier
Parkinson disease (PD) is the second most progressive neurodegenerative disorder of the
central nervous system (CNS) in the elderly, causing motor impediments and cognitive …

Identification of molecular network of gut‐brain axis associated with neuroprotective effects of PPARδ‐ligand erucic acid in rotenone‐induced Parkinson's disease …

İ Ünal, D Cansız, MG Sürmen, S Sürmen… - European Journal of …, 2023 - Wiley Online Library
Disruption of the gut‐brain axis in Parkinson's disease (PD) may lead to motor symptoms
and PD pathogenesis. Recently, the neuroprotective potential of different PPARδ‐agonists …

Proteomics in human Parkinson's disease: present scenario and future directions

A Dixit, R Mehta, AK Singh - Cellular and molecular neurobiology, 2019 - Springer
Parkinson's disease (PD) is an age-related, threatening neurodegenerative disorder with no
reliable treatment till date. Identification of specific and reliable biomarker is a major …

Escalating Bi-Directional Feedback Loops between Proinflammatory Microglia and Mitochondria in Ageing and Post-Diagnosis of Parkinson's Disease

SM Ravenhill, AH Evans, SG Crewther - Antioxidants, 2023 - mdpi.com
Parkinson's disease (PD) is a chronic and progressive age-related neurodegenerative
disease affecting up to 3% of the global population over 65 years of age. Currently, the …

Stress system and related biomarkers in Parkinson's disease

A Bougea, L Stefanis, G Chrousos - Advances in Clinical Chemistry, 2022 - Elsevier
Parkinson's disease (PD) is characterized by complex motor and non-motor symptoms that
vary in onset, severity, response to treatment, and disability. The unpredictable and …

Proteomic and targeted metabolomic studies on a silkworm model of Parkinson's disease

F Zhu, H Chen, J Han, W Zhou, Q Tang… - Journal of Proteome …, 2022 - ACS Publications
Parkinson's disease (PD) is a chronic and progressive movement disorder that is
characterized by the loss of dopaminergic neurons in the brain. Animal models of PD have …

Gentisic acid exerts neuroprotective effects in neurotoxin-induced Parkinson's disease model in zebrafish: Cross-talk between pathways related with …

D Cansız, İ Ünal, MG Sürmen, S Sürmen, Z Sezer… - Brain Research, 2024 - Elsevier
Given that global prevalence of Parkinson's disease (PD) is expected to rise over the next
few decades, understanding the mechanisms and causes of PD is critical. With emphasis on …

Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens

R Cocoș, BO Popescu - Human Genomics, 2024 - Springer
Neurodegenerative diseases present complex genetic architectures, reflecting a continuum
from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data …