Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

The “Warburg effect,” an elevation in aerobic glycolysis, may be a fundamental property of
cancer cells. For cancer diagnosis and treatment, it would be valuable if elevated glycolytic …

Imaging of enzyme activity in living subjects promises many applications in both basic and
translational researches from helping elucidate the enzyme function and mechanism in …

Hyaluronidases are a family of five human enzymes that have been differentially implicated
in the progression of many solid tumor types, both clinically and in functional studies …

Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH,
increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic …

The ability to identify key biomolecules and molecular changes associated with cancer
malignancy and the capacity to monitor the therapeutic outcome against these targets is …

Introduction 3. MRI contrast mechanisms 4. Exogenous MRI contrast agents 5. Responsive
MRI contrast agents 5.1. Molecular imaging of proteins 5.1. 1. Contrast agents that bind to …

Indocyanine green (ICG) encapsulated hyaluronic acid (HA) nanogels were first studied for
highly selective detection of specific cancers and lymph nodes via hyaluronidase sensitive …

This study aims at developing an innovative theranostic approach for lung tumor and
metastases treatment, based on Boron Neutron Capture Therapy (BNCT). It relies on to the …