Vesicle exocytosis releases content to mediate many biological events, including synaptic
transmission essential for brain functions. Following exocytosis, endocytosis is initiated to …

Memory is central to many aspects of behaviour, but in spite of a long interest in its neural
basis, empirical evidence of the nature of the hypothetical pathway that is left in the …

It has been 30 years since the discovery that repeated electrical stimulation of neural
pathways can lead to long-term potentiation in hippocampal slices. With its relevance to …

To elucidate molecular, cellular, and circuit changes that occur in the brain during learning,
we investigated the role of a glutamate receptor subtype in fear conditioning. In this form of …

Vesicular secretion of neurotransmitter is essential for neuronal communication. Kiss-and-
run is a mode of membrane fusion and retrieval without the full collapse of the vesicle into …

Long-term potentiation has captured the attention of neuroscientists for over two decades. It
has provided motivation to investigate the detailed mechanisms of synaptic transmission …

The properties of synaptic transmission were first elucidated at the neuromuscular junction.
More recent work has examined transmission at synapses within the brain. Here we review …

The fusion pore is the first crucial intermediate formed during exocytosis, yet little is known
about the mechanisms that determine the size and kinetic properties of these transient …

Long-term potentiation (LTP) has been studied extensively at CA1 synapses of the
hippocampus, and there is evidence implicating both postsynaptic and presynaptic changes …

Regulated exocytosis and endocytosis are critical to the function of many intercellular
networks, particularly the complex neural circuits underlying mammalian behavior. Kiss-and …